Fluctuations in estrogen seem to trigger headaches in many women with known migraines. Women with a history of migraines often report headaches immediately before or during their periods, when they have a major drop in estrogen. Others have an increased tendency to develop migraines during pregnancy or menopause. Hormonal medications — such as oral contraceptives and hormone replacement therapy — also may worsen migraines, though some women find it's beneficial to take them.
Hormones
Fluctuations in estrogen seem to trigger headaches in many women with known migraines. Women with a history of migraines often report headaches immediately before or during their periods, when they have a major drop in estrogen. Others have an increased tendency to develop migraines during pregnancy or menopause. Hormonal medications — such as oral contraceptives and hormone replacement therapy — also may worsen migraines, though some women find it's beneficial to take them.
Brain chemicals - serotonin

Imbalances in brain chemicals, including serotonin — which helps regulate pain in the nervous system — may be the cause of migraines.
Serotonin levels drop during migraine attacks. This may trigger our trigeminal system to release substances called neuropeptides, which travel to the brain's outer covering (meninges). The result is headache pain.
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